Abstract

Background: Hypothyroidism commonly affects elderly individuals, involving complex interactions within the endocrine system. This study explores the relationship between various endocrine factors and the effectiveness of thyroid hormone replacement therapy (THRT) in an elderly hypothyroid population.

Methods: A total of 150 elderly patients diagnosed with hypothyroidism and subsequently treated with THRT were enrolled. Clinical evaluations, laboratory data, and symptom assessments were recorded. Multivariate regression models were then employed to investigate the impact of endocrine changes on THRT efficacy.

Results: The overall success rate of THRT was 85.3%, with a significant association between hormone levels and treatment effectiveness. When stratified by body mass index (BMI), patients with a normal BMI (18.5–24.9) demonstrated the highest success rate (93.5%), while those classified as obese (BMI ≥ 30) showed the lowest (75.8%).  Furthermore, both insulin and leptin levelswere significantly correlated with THRT outcomes; abnormal levels were linked to diminished response rates. Logistic regression confirmed that insulin and leptin were strong predictors of THRT efficacy, highlighting their critical roles in guiding treatment.

Conclusion: Endocrine factors—particularly insulin and leptin—exert a notable influence on the effectiveness of THRT in elderly hypothyroid patients. Early evaluation of these parameters may enable more targeted and successful treatment strategies, ultimately improving therapeutic outcomes in this population.