Abstract

Frailty is a significant clinical syndrome associated with functional decline and increased mortality in older adults. This review focuses on the relationship between physical activity/exercise interventions and frailty. The pathophysiology of frailty, including inflammation, oxidative stress, and its impact on skeletal muscle, respiratory, cardiovascular, endocrine, and nervous systems, underscores the importance of physical activity in frailty management. Physical activity/exercise may reduce age-related oxidative damage and chronic inflammation across various systems, thereby preventing or treating the frailty phenotype and promoting healthy aging. Recent evidence demonstrates that physical activity/exercise could prevent and treat frailty-related physical  impairment in the elderly. Further research is warranted to determine the optimal physical activity regimen for frailty prevention and treatment.