Abstract

Backgrounds: Current literature presents conflicting findings regarding the association between insulin resistance and bone mineral density. While some studies demonstrate a significant correlation, others do not. Furthermore, there is a lack of research investigating the correlation between the metabolic score of insulin resistance index and bone mineral density. Therefore, this study aims to examine the relationship between these two parameters.

Methods: A cross-sectional study was conducted, which included data from five cycles of the National Health and Nutrition Examination Survey with a total of 6769 subjects. Multiple linear regression was utilized to analyze the association between the variables.

Results: After adjusting for potential confounding factors, the results showed a positive correlation between the metabolic score of insulin resistance and total femur (Per-standard deviation [Per-SD]: ß = 0.060; Quartile: ß = 0.150, both p < 0.001), femur neck (Per-SD: ß = 0.049; Quartile: ß = 0.115, both p < 0.001), and lumbar spine (Per-SD: ß = 0.040; Quartile: ß = 0.108, both p < 0.001) bone mineral density, regardless of whether the formerwas analyzed as a continuous or categorical variable. As the metabolic score of insulin resistance increased, this correlation became more prominent (p for trend < 0.001). Subgroup analyses for gender, age, hypertension, and diabetes all came to conclusions consistent with the above results.

Conclusion: Our study findings indicate a positive correlation between insulin resistance and bone density.