Abstract

Non-typhoidal Salmonella (NTS) is a common pathogen causative of gastrointestinal infections. However, it can also lead to extra-intestinal infections, such as urinary tract infections or bacteremia, in some specific patient groups, including HIV-infected patients, patients receiving immunosuppressive agents, or those with urological malignancy, while there are few cases with both underlying autoimmune disease and hematologic malignancy. NTS-related sepsis may lead to higher mortality and complication rates in these patients. Here,we report the case of a 62-year-oldwoman who presented to our hospital with suspected left uterovesical junction stone with hydronephrosis complicated by urinary tract infection. After an episode of urosepsis, the patient was admitted to the intensive care unit and received intravenous antibiotic treatment with ertapenem, which improved her vital signs. A double-J stent was inserted in the left ureter to prevent obstruction by an abdominal tumor. Furthermore, blood and urine cultures identified Salmonella enterica group D. The tumor was diagnosed as diffuse large B-cell lymphoma. We report the rare case of a patient with NTS bacteriuria and bacteremia, underlying systemic lupus erythematosus (SLE), and diffuse large B-cell lymphoma. Prolonged antibiotic treatment is required in SLE patients with NTS, bacteriuria, and bacteremia.