Abstract

Background: To evaluate the efficacy and safety of intravenous thrombolytic therapy (TT) using low-dose rt-PA in a broadened therapeutic window (TW) for ischemic stroke treatment under multimode magnetic resonance imaging (MRI) monitoring.

Methods: A total of 45 patients with ischemic stroke occurring within 4.5–6 h prior to treatment were divided into two groups: thrombolytic group (Group A) and non-thrombolytic group (Group B). Another set of 25 patients with ischemic stroke occurring within 4.5 h were classified into Group C. Low-dose rt-PA was administered in Group A, standard-dose rt-PA in Group C, and normal therapy in Group B. All the patients were evaluated using the National Institutes of Health Stroke Scale (NIHSS) scores before and 24 h after treatment and modified Rankin scale (mRS) scores 90 days after treatment.

Results: The post-treatment NIHSS score and day-90 mRS score in Groups A and C were significantly different from those in Group B (p < 0.05).

Conclusion: Intravenous TT using low-dose rt-PA in a broadened TW for ischemic stroke treatment under multimode MRI monitoring is safe and effective.