Abstract

Background: The delay and increase in the number of Alzheimer's dementia patients cause many impacts, both from increased morbidity and moral and material losses. Biomarkers such as brain imaging (magnetic resonance imaging (MRI) and positron emission tomography (PET) Scan) need to be done immediately in the diagnosis of suspected Alzheimer's dementia. This study aimed to analyze the relationship between the hippocampalmyo-inositol (MI)/ N-acetylaspartate (NAA) ratio and the severity of Mini-Mental State Examination (MMSE) in Alzheimer's dementia patients.

Methods: MMSE and Hachinski scores were assessed by a neurologist, and the hippocampal mI/NAA ratio was calculated using MRI and MR spectroscopy.

Results: The right hippocampal MI/NAA was significant with the incidence of Alzheimer's (p value = 0.018).

Conclusion: There was a correlation between right MI/NAA and the severity of MMSE in Alzheimer's dementia patients.