Abstract

Background: To investigate the relationship between procalcitonin, homocysteine and severity of coronary artery disease (CADs) in type 2 diabetic patients (T2DM).

Methods: A total of 121 patients with type 2 diabetes were divided into diabetic group, diabetic patients with coronary heart disease group (patients with stable angina pectoris and acute coronary syndrome group and combined group), another 50 healthy controls were analyzed between the clinical data, according to the number of coronary lesions, Gensini score group and multiple regression analysis of diabetes mellitus PCT and Hcy levels in patients with coronary artery disease.

Results: There was a statistically significant difference in diabetes course, BMI, Glu, HbA1c, Hcy, PCT between the T2DM-CHD groups compared with the C and T2MD groups. Gensini scores of the SAP and ACS groups were significantly positively correlated with Hcy and PCT levels (r = 0.137, r = 0.232, r = 0.526, r = 0.545, p < 0.05). Two, three coronary lesions group Hcy and PCT levels were higher than those of the C group (p < 0.05). Multivariate logistic regression analysis showed that HbA1c (OR 1.58, 95% CI 1.162.80, p = 0.016), Hcy (odds ratio [OR] 2.27, 95% CI 1.242.53, p = 0.002) and PCT (OR 1.86, 95% CI 1.293.98, p = 0.024) were the independent influence factor of Gensini score in T2DM-CHD patients.

Conclusion: This study shows that the severity of CADs with the increase of PCT and Hcy levels in patients with T2DM-CHD. It is of great value in predicting CADs.