Abstract

Background: This study aimed to analyze the correlation between the expression levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) and omentin-1 and the severity of coronary artery disease in the elderly.

Methods: The clinical data of 117 elderly patients with coronary heart were retrospectively analyzed and divided into stable angina pectoris (SAP) group, unstable angina pectoris (UAP) group, and acute myocardial infarction (AMI) group. Another 50 health volunteers were included as control group.

Results: Serum sLOX-1 level in AMI group > UAP group > SAP group > control group, and omentin-1 level in AMI group < UAP group < SAP group < control group (p < 0.05); ROC curve results showed that AUCs of sLOX-1, omentin-1 and the combination of both predicted the occurrence of coronary heart disease were 0.930, 0.887, and 0.926. The serum sLOX-1 level, Gensini score, PWVβ, β, IMT, I CTP, CatK,MMP-2, MMP-9, TNF-α, hs-CRP, IL-6, IL-10 in severe group > moderate group >mild group. The omentin-1 level, CAC in severe group < moderate group < mild group (p < 0.05).

Conclusion: Serum sLOX-1 and omentin-1 levels are closely related to the severity of disease, carotid ultrasound parameters, plaque stability and  inflammatory response in elderly patients with coronary artery disease, which can be used as biological markers to predict the occurrence of coronary artery disease.